Explore how NAD+ impacts egg quality, embryo development, and fertility treatments.
At QelizA, we understand that fertility is not just about reproductive health—it’s about the health of your entire body, down to the cellular level. This is where NAD⁺ (Nicotinamide Adenine Dinucleotide), a vital coenzyme, plays a transformative role. As research advances, we’re seeing how NAD⁺ and other cellular-boosting supplements can optimize fertility outcomes, particularly for those facing age-related challenges.

What is NAD⁺ and Why Does it Matter?
NAD⁺ is a coenzyme found in all living cells, crucial for energy production, DNA repair, and combating oxidative stress. However, its levels decline as we age, which directly impacts cellular function and reproductive health.
The Connection Between NAD⁺ and Fertility
• Oocyte (Egg) Quality: Studies show a direct correlation between declining NAD⁺ levels and reduced egg quality in women over 30.
• Embryo Development: NAD⁺ is essential for mitochondrial energy production, which supports proper embryo formation and viability.
The Science Behind NAD⁺ and Reproductive Health
Research indicates that NAD⁺ levels decline with age, contributing to reduced oocyte (egg cell) quality and female fertility. Studies have explored the potential of NAD⁺ supplementation to counteract these effects. Figure 1.
These findings suggest that NAD⁺ supplementation holds promise for enhancing oocyte quality and female fertility, particularly in the context of reproductive aging. However, further research is necessary to fully understand the mechanisms involved and to develop effective clinical applications.

Figure 1. – Detailed Explanation of the Graph:
NAD⁺ Levels and Aging:
• NAD⁺ levels decline significantly with age. In the chart, we see that NAD⁺ levels are highest in the 20s (100%) but drop to 40% by the age of 50.
• This decline is linked to reduced energy production, diminished cellular repair capacity, and increased oxidative stress—all factors that impair reproductive health.
A notable study demonstrated that administering nicotinamide mononucleotide (NMN), a precursor to NAD⁺, to aged female mice rejuvenated oocyte quality and restored fertility. This treatment also improved embryo development, suggesting that replenishing NAD⁺ levels could reverse reproductive aging effects.
Another review highlighted the role of NAD⁺ in ovarian aging, emphasizing its importance in maintaining oocyte quality. The review suggests that NAD⁺ supplementation could be a promising strategy to enhance female reproductive health by mitigating age-related decline in oocyte quality.
Additionally, research has examined the roles of NAD⁺, sirtuins, and poly-ADP-ribose polymerases (PARPs) in fertility. Elevating NAD⁺ levels through dietary supplements in aged subjects improved oocyte quality and embryo development, indicating that NAD⁺-elevating treatments may benefit reproductive health.

Mechanisms by Which NAD⁺ Impacts Fertility
• DNA Repair: NAD⁺ supports sirtuins and PARPs, proteins involved in DNA repair, which are essential for maintaining healthy egg cells.
• Energy Production: It is critical for mitochondrial function, which provides energy for cellular processes, including oocyte maturation.
• Oxidative Stress: Lower NAD⁺ levels increase susceptibility to oxidative stress, harming reproductive cells.

Figure 2. – Rejuvenation of Oocytes:
This bar chart demonstrates the effect of NAD⁺ supplementation on oocyte quality across different age groups.
Observations:
1. Control Group (Light Blue):
• Oocyte quality declines steadily with age, with only 30% high-quality oocytes in women in their 50s.
2. NAD⁺ Supplemented Group (Orange):
• NAD⁺ supplementation improves oocyte quality significantly, particularly in older age groups (e.g., 40s and 50s).
Key Takeaways:
• Studies in aged mice showed that supplementation with NAD⁺ precursors (like NMN or NR) restored oocyte quality and improved embryo development.
• In younger age groups, the effect of supplementation is marginal since NAD⁺ levels are already higher.
• In older age groups, supplementation boosts oocyte quality by 20% or more, showing promise for addressing age-related fertility challenges.
Clinical Relevance:
• While most studies are preclinical, initial findings suggest potential benefits of NAD⁺ supplementation for older women or those facing fertility challenges.
Recommendations for Future Study:
• Clinical trials are needed to confirm the safety and efficacy of NAD⁺ precursors in improving fertility.
• Research should explore long-term impacts on offspring health and the best protocols for supplementation.

Patient-Friendly Tips for Enhancing Fertility
1. Nourish Your Body
• Eat Fertility-Friendly Foods: Include high quality red meat, berries, nuts, and fatty fish for antioxidants and healthy fats.
• Supplement Wisely: Consider NAD⁺ precursors like NMN, plus CoQ10, Omega-3s, and folate for egg health.
2. Prioritize Restorative Practices
• Get Enough Sleep: Your body repairs itself during deep sleep—aim for 7–8 hours nightly.
• Stay Active: Moderate exercise boosts circulation and cellular function.
3. Reduce Stress
• Chronic stress impacts hormone balance. Try yoga, meditation, or even daily walks to stay calm.
4. Consider Advanced Therapies
• At Qeliza, our Fertility IV Therapy is tailored to support reproductive health with NAD⁺, antioxidants, and essential nutrients.

Why Choose Qeliza for Fertility Support?
At Qeliza Aesthetic Lounge, we combine science and care to offer:
1. Fertility IV Therapy: Customized with nutrients for cellular rejuvenation.
2. NAD+: Loading dose protocol (Dr Koniver’s Protocol)
3. High-Quality Supplements: NMN, CoQ10, Omega-3s, and more to optimize reproductive health.
4. Advanced Therapies: Peptides for hormone balance, red light therapy for cellular repair, and PEMF for overall vitality.
Take the Next Step in Your Fertility Journey
Fertility is deeply personal, but science-backed solutions can make all the difference. By focusing on cellular health with NAD⁺, other nutrients and holistic lifestyle changes, you can optimize your chances naturally.
Citations:
NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Bertoldo, M. J., et al. Cell Reports, 2020.
NAD+, Sirtuins and PARPs: Enhancing Oocyte Developmental Competence and Embryo Production. Gibson, T. C., et al. Frontiers in Cell and Developmental Biology, 2022.
Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model. Min, H., et al. Antioxidants, 2021.