{"id":4390,"date":"2025-08-11T20:57:07","date_gmt":"2025-08-11T20:57:07","guid":{"rendered":"https:\/\/qelizaesthetics.com\/sirtuins-dna-handymen\/"},"modified":"2025-08-11T20:57:07","modified_gmt":"2025-08-11T20:57:07","slug":"sirtuins-dna-handymen","status":"publish","type":"post","link":"https:\/\/qelizaesthetics.com\/el\/sirtuins-dna-handymen\/","title":{"rendered":"\u03a3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2: Sirtuins: \u0395\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">\u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b6\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 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\u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd, \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><b>\u0397 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c4\u03b7\u03c2<\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u0397 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 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\u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0395\u03be\u03c9\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u03a0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b9\u03ce\u03b4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b7\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c6\u03c9\u03c4\u03cc\u03c2, \u03b7 \u03b9\u03bf\u03bd\u03af\u03b6\u03bf\u03c5\u03c3\u03b1 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 (\u03c0.\u03c7. \u03b1\u03ba\u03c4\u03af\u03bd\u03b5\u03c2 \u03a7), \u03bf\u03b9 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 (\u03c0.\u03c7. \u03ba\u03b1\u03c0\u03bd\u03cc\u03c2, \u03c1\u03cd\u03c0\u03bf\u03b9) \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b2\u03bb\u03ac\u03c8\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03bf DNA.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0395\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03b4\u03b7 \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03bf\u03c5 (ROS), \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf DNA. \u0386\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 DNA \u03ae \u03c4\u03bf\u03bd \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u0397 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c0\u03cc\u03bd\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 DNA, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c0\u03cc\u03bd\u03b7\u03c3\u03b7 \u03ae \u03b7 \u03c4\u03ac\u03c3\u03b7, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf DNA.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u03a4\u03b1 \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03c4\u03bf\u03c5 DNA \u03ae \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03b9\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ae \u03c3\u03c0\u03b1\u03c3\u03af\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 \u03c4\u03bf\u03c5 DNA.<\/span><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>\u0397 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd:<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03b6\u03b7\u03bc\u03b9\u03ce\u03bd<\/b><span style=\"font-weight: 400;\">: \u039c\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03c5\u03bd \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c3\u03c4\u03bf DNA \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c7\u03bf\u03cd\u03c2 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2. \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03ba\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA<\/b><span style=\"font-weight: 400;\">: \u0397 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03b9\u03c3\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA. \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b9\u03ba\u03b1\u03bd\u03ac \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0393\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5<\/b><span style=\"font-weight: 400;\">: \u0397 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 (\u03bc\u03cc\u03bd\u03b9\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5) \u03ae \u03b7 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 (\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2). \u039f\u03b9 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03bf\u03b4\u03ce\u03bd<\/b><span style=\"font-weight: 400;\">: \u0397 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae. \u0397 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd, \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 (\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae), \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03c3\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1<\/b><span style=\"font-weight: 400;\">: \u0397 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">\u039f\u03b9 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2, \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c4\u03b7\u03bd \u03b1\u03ba\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5. \u0397 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03bc\u03b5\u03c4\u03c1\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03b5\u03af\u03bd\u03b1\u03b9 \u03b6\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03b3\u03b9\u03bf\u03cd\u03c2 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>\u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2, \u03bf\u03b9 \u03b5\u03c0\u03b9\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c4\u03bf\u03c5 DNA<\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03bf\u03c5 DNA \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA<\/b><span style=\"font-weight: 400;\">: \u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03ba\u03bf\u03c0\u03ae \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd (BER), \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03ba\u03bf\u03c0\u03ae \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd (NER) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c0\u03b1\u03c3\u03b9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03ad\u03bb\u03b9\u03ba\u03b1\u03c2 (DSBR). \u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03ae \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0391\u03c0\u03bf\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA<\/b><span style=\"font-weight: 400;\">: \u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA, \u03cc\u03c0\u03c9\u03c2 \u03b5\u03ba\u03b5\u03af\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 NHEJ (non-homologous end joining) \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c3\u03c0\u03b1\u03c3\u03b9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03ad\u03bb\u03b9\u03ba\u03b1\u03c2. \u0397 \u03b1\u03c0\u03bf\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA, \u03c0\u03c1\u03bf\u03c9\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03bc\u03cc\u03bb\u03bf\u03b3\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd<\/b><span style=\"font-weight: 400;\">: \u0388\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2, \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b7 SIRT6, \u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03bf\u03bc\u03cc\u03bb\u03bf\u03b3\u03bf \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc, \u03ad\u03bd\u03b1\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b1\u03c3\u03b9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03ad\u03bb\u03b9\u03ba\u03b1\u03c2 \u03c3\u03c4\u03bf DNA. \u0397 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03b7\u03c2 SIRT6 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c3\u03c4\u03bf DNA.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA<\/b><span style=\"font-weight: 400;\">: \u039a\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA, \u03bf\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c9\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2. \u03a3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b4\u03bf\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03bf\u03c5 DNA.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u039c\u03b5\u03c4\u03c1\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03c1\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 SIRT1 \u03ba\u03b1\u03b9 SIRT3, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd \u03b1\u03ba\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bf\u03be\u03b5\u03b9\u03b4\u03bf\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03c1\u03b5\u03c2<\/b><span style=\"font-weight: 400;\">: \u039f\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c4\u03c1\u03b5\u03c2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b9\u03ce\u03b4\u03bf\u03c5\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c7\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c9\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03c3\u03b9\u03c1\u03c4\u03bf\u03c5\u03af\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c3\u03c4\u03bf DNA \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u039f\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>\u03a0\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c9\u03b8\u03ae\u03c3\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 Situin<\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u0388\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Sirtuin, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c4\u03bf\u03c5 SIRT1, \u03c4\u03bf\u03c5 \u03c0\u03b9\u03bf \u03ba\u03b1\u03bb\u03ac \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bc\u03ad\u03bb\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 Sirtuin:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0398\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2<\/b><span style=\"font-weight: 400;\">: \u039f \u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2, \u03ae \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03af\u03b4\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03c5\u03c0\u03bf\u03c3\u03b9\u03c4\u03b9\u03c3\u03bc\u03cc, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03b5\u03c1\u03b5\u03b8\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 SIRT1. \u0395\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 NAD^+, \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 SIRT1, \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0394\u03b9\u03b1\u03bb\u03b5\u03af\u03c0\u03bf\u03c5\u03c3\u03b1 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1<\/b><span style=\"font-weight: 400;\">: \u0397 \u03b4\u03b9\u03b1\u03bb\u03b5\u03af\u03c0\u03bf\u03c5\u03c3\u03b1 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2, \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 SIRT1. \u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b7 \u03b4\u03b9\u03b1\u03bb\u03b5\u03af\u03c0\u03bf\u03c5\u03c3\u03b1 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 NAD^+ \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7<\/b><span style=\"font-weight: 400;\">: \u0397 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b7 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 SIRT1. \u0391\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 NAD^+ \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03bf SIRT1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a1\u03b5\u03c3\u03b2\u03b5\u03c1\u03b1\u03c4\u03c1\u03cc\u03bb\u03b7<\/b><span style=\"font-weight: 400;\">: \u0397 \u03c1\u03b5\u03c3\u03b2\u03b5\u03c1\u03b1\u03c4\u03c1\u03cc\u03bb\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03c6\u03b1\u03b9\u03bd\u03cc\u03bb\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03cc\u03ba\u03ba\u03b9\u03bd\u03b1 \u03c3\u03c4\u03b1\u03c6\u03cd\u03bb\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03c5\u03c4\u03ac. \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03bf SIRT1 \u03ba\u03b1\u03b9 \u03bc\u03b9\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03c3\u03c5\u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03b1\u03bd\u03c4\u03af\u03ba\u03c4\u03c5\u03c0\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 NAD+: \u03a3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd NAD+ \u03bc\u03b5 NAD+<\/b><span style=\"font-weight: 400;\"> \u03c0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03c1\u03b9\u03b2\u03bf\u03b6\u03af\u03c4\u03b7 \u03bd\u03b9\u03ba\u03bf\u03c4\u03b9\u03bd\u03b1\u03bc\u03b9\u03b4\u03af\u03bf\u03c5 (NR) \u03ae \u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03bd\u03b9\u03ba\u03bf\u03c4\u03b9\u03bd\u03b1\u03bc\u03b9\u03b4\u03af\u03bf\u03c5 (NMN), \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Sirtuin. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03c0\u03b9\u03c3\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 SIRT1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 NAD+.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03c1\u03bc\u03ad\u03bc\u03c9\u03c3\u03b7<\/b><span style=\"font-weight: 400;\">: \u039f\u03b9 \u03ae\u03c0\u03b9\u03bf\u03b9 \u03c3\u03c4\u03c1\u03b5\u03c3\u03bf\u03b3\u03cc\u03bd\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 (\u03c0.\u03c7. \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03ac\u03bf\u03c5\u03bd\u03b1\u03c2) \u03ae \u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 (\u03c0.\u03c7. \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ac), \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Sirtuin \u03c9\u03c2 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03ae \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u038e\u03c0\u03bd\u03bf\u03c2<\/b><span style=\"font-weight: 400;\">: \u039f \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c4\u03b9\u03ba\u03cc\u03c2 \u03cd\u03c0\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 Sirtuin. \u03a4\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03cd\u03c0\u03bd\u03bf\u03c5 \u03ae \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03cd\u03c0\u03bd\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 NAD^+ \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b2\u03bb\u03ac\u03c8\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 Sirtuin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u03a5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae<\/b><span style=\"font-weight: 400;\">: \u0397 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1\u03c2 \u03c3\u03b5 \u03b8\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Sirtuin \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2. \u039f\u03b9 \u03b4\u03af\u03b1\u03b9\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ae \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03c4\u03c1\u03cc\u03c6\u03b9\u03bc\u03b1 \u03c6\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03c6\u03c1\u03bf\u03cd\u03c4\u03b1, \u03c4\u03b1 \u03bb\u03b1\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b7\u03bc\u03b7\u03c4\u03c1\u03b9\u03b1\u03ba\u03ac \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ad\u03c3\u03b5\u03c9\u03c2, \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 Sirtuin.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">\u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Sirtuin, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc, \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2, \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1. \u0397 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03b6\u03c9\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b3\u03b9\u03ae \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/span><\/p>\n<div>\n<p style=\"text-align: right;\"><b>\u039c\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1<\/b><\/p>\n<\/div>\n<hr>\n<p>&nbsp;<\/p><\/p>","protected":false},"excerpt":{"rendered":"<p>Sirtuins are a family of proteins crucial for regulating various cellular processes essential to health and longevity. These proteins, dependent on the coenzyme NAD^+, are known for their roles in aging, gene expression, metabolism, and stress response. Sirtuins exert their effects primarily through deacetylating histones and other proteins, influencing chromatin structure and gene transcription. Their [&hellip;]<\/p>","protected":false},"author":1,"featured_media":4407,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_thinkrank_schema_form_data":"","_thinkrank_selected_schema_type":"","_thinkrank_additional_schemas":"","_thinkrank_canonical_url":"","_thinkrank_og_title":"","_thinkrank_og_description":"","_thinkrank_og_image":"","_thinkrank_twitter_title":"","_thinkrank_twitter_description":"","_thinkrank_twitter_image":"","_thinkrank_imported_from":"","_thinkrank_focus_keywords":[],"_thinkrank_focus_keyword":"","_thinkrank_robots_meta_enabled":0,"_thinkrank_robots_meta":"","_thinkrank_advanced_robots_meta":"","_thinkrank_exclude_from_search":0,"_thinkrank_exclude_from_archives":0,"_thinkrank_primary_category":0,"_xspeed_no_cache":false,"_xspeed_expiry_hours":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/posts\/4390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/comments?post=4390"}],"version-history":[{"count":0,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/posts\/4390\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/media\/4407"}],"wp:attachment":[{"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/media?parent=4390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/categories?post=4390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/qelizaesthetics.com\/el\/wp-json\/wp\/v2\/tags?post=4390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}